Accepted for Publication: January 27, 2015.
Published Online: March 12, 2015. doi:10.1001/jamaoncol.2015.0197.
Study concept and design: Joshi, Hopper, Potter, Kucherlapati, Syngal.
Acquisition, analysis, or interpretation of data: Yurgelun, Masciari, Joshi. Mercado, Lindor, Gallinger, Hopper, Jenkins, Buchanan, Newcomb, Potter, Haile, Kucherlapati, Syngal.
Drafting of the manuscript: Yurgelun, Masciari, Joshi, Mercado, Haile, Kucherlapati.
Critical revision of the manuscript for important intellectual content: Yurgelun,Joshi, Lindor, Gallinger, Hopper, Jenkins, Buchanan, Newcomb, Potter, Kucherlapati, Syngal.
Statistical analysis: Mercado.
Obtained funding: Gallinger, Hopper, Jenkins, Newcomb, Kucherlapati, Syngal.
Administrative, technical, or material support: Masciari, Joshi, Mercado, Hopper, Buchanan, Newcomb, Potter, Haile, Kucherlapati, Syngal.
Study supervision: Hopper, Newcomb, Haile, Kucherlapati, Syngal.
Conflict of Interest Disclosures: Dr Yurgelun reports receiving research funding from Myriad Genetic Laboratories. Dr Syngal does not receive research funding from Myriad; however, she is Dr Yurgelun’s mentor and collaborator on the projects that will be supported by Myriad. No other disclosures are reported.
Funding/Support: This study was funded by the National Institutes of Health (NIH) (National Cancer Institute [NCI]) K24CA113433 (Dr Syngal) and UM1CA167551 (Dr Haile), as well as an American Gastroenterological Association (AGA) Translational Research Award (Drs Syngal and Kucherlapati). The Colon Cancer Family Registry (CCFR) was supported by the NCI, NIH, of Health under RFA No. CA-95-011 and through cooperative agreements with members of the CCFR and Principal Investigators. Collaborating centers include the Australasian Colorectal Cancer Family Registry, Colon Cancer Family Registry: USC Consortium, Mayo Clinic Cooperative Family Registry for Colon Cancer Studies, Ontario Registry for Studies of Familial Colorectal Cancer, and Seattle Colorectal Cancer Family Registry.
Role of Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Group Information: The CCFR principal investigators are Robert W. Haile, PhD, Stanford Cancer Institute, Stanford, California; Mark A. Jenkins, PhD, University of Melbourne, Carlton, Victoria, Australia; and Noralane M. Lindor, MD, Mayo Clinic, Scottsdale, Arizona.
Disclaimer: The content of this article does not necessarily reflect the views or policies of the NCI or any of the collaborating centers in the CCFR, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government or the CCFR.
Previous Presentations: Preliminary data from this study were presented as an abstract at the annual Digestive Disease Week; May 2-5, 2010; New Orleans, Louisiana; and as an oral abstract at the Annual Meeting of the Collaborative Group of the Americas on Inherited Colorectal Cancer; September 15-16, 2014; New Orleans, Louisiana.
Additional Contributions: We thank all staff and study participants of the CCFR for their invaluable contributions to this project.