Accepted for Publication: June 17, 2015.
Open Access: This article is published under the JAMA Oncology open access model and is free to read on the day of publication.
Published Online: August 13, 2015. doi:10.1001/jamaoncol.2015.2690.
Study concept and design: Kurian, Anderson, Kobayashi, Shannon, Tung, Ford, Lincoln, Ellisen.
Acquisition, analysis, or interpretation of data: Desmond, Kurian, Gabree, Mills, Anderson, Kobayashi, Horick, Yang, Tung, Ford, Lincoln, Ellisen.
Drafting of the manuscript: Desmond, Mills, Anderson, Kobayashi, Tung, Lincoln, Ellisen.
Critical revision of the manuscript for important intellectual content: Desmond, Kurian, Gabree, Anderson, Kobayashi, Horick, Yang, Shannon, Tung, Ford, Lincoln, Ellisen.
Statistical analysis: Desmond, Kobayashi, Horick, Yang, Lincoln.
Obtained funding: Kurian, Ford, Lincoln, Ellisen.
Administrative, technical, or material support: Desmond, Gabree, Mills, Kobayashi, Yang, Shannon, Ford, Lincoln.
Study supervision: Tung, Ford, Lincoln, Ellisen.
Generation of data: Anderson.
Conflict of Interest Disclosures: Drs Kurian and Ford receive research funding from Myriad Genetics. Drs Anderson, Kobayashi, and Yang and Mr Lincoln are employees of Invitae Corporation, a testing laboratory that furnished the 29-gene panel test results used in this study. Separately from this study, Dr Ford is a paid member of Invitae’s advisory board, and Dr Ellisen is a consultant to Biorefernce/GeneDx Laboratories. No other disclosures are reported.
Funding/Support: This study was funded by unrestricted philanthropic gifs from the MGH Friends Fighting Breast Cancer and the Tracey Davis Memorial Fund (Ms Desmond and Dr Ellisen) and by the Breast Cancer Research Foundation (Drs Kurian and Ford).
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. This study was an academic collaboration and not a sponsored research project: no other funding or compensation was provided by genetic testing companies.
Additional Contributions: The authors thank Andrew Schultz, BS, and Devika Salunke, MS, from MGH for sample processing; Curtis Kautzer, BS, Michael Kennemer, MS, Dan Kvitek, PhD, and Angela Chou, BS, from Invitae, for data generation; Raji Pillai, PhD, from Invitae, for manuscript review; and John Garcia, PhD, Blanca Herrera, PhD, Yuan-Yuan Ho, PhD, Keith Nykamp, PhD, Nila Patil, PhD, and Janita Thusberg, PhD, from Invitae, for variant interpretation. None of the acknowledged persons received compensation for their contributions beyond that received during the normal course of their employment.