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Original Investigation | June 23, 2016 FREE ONLINE FIRST

Candesartan for Preventing Trastuzumab-Related Cardiotoxic Effects in Breast Cancer

This randomized clinical trial compares candesartan vs placebo for preventing LVEF reduction in patients with breast cancer treated with trastuzumab.
Invited Commentary

Review | June 23, 2016 ONLINE FIRST

Tumor-Infiltrating Lymphocytes in Breast Cancer Subtypes

This review examines the median percentage of patients with breast cancer with no, intermediate, or high levels of tumor-infiltrating lymphocytes and assesses variations in lymphocytic cell subsets across breast cancer subtypes.

Original Investigation | June 16, 2016 ONLINE FIRST

Extent of Resection and Survival in Glioblastoma

This meta-analysis summarizes published estimates of association between extent of glioblastoma multiforme resection and overall and progression-free survival.

Review | June 16, 2016 ONLINE FIRST

Biomarkers for PD-1/PD-L1 Inhibitor Use in Non–Small-Cell Lung Cancer

This review summarizes available and candidate biomarkers for the selection of patients who might benefit from the use of PD-1/PD-L1 inhibitors for the treatment of non–small-cell lung cancer.

Editorial | June 15, 2016 ONLINE FIRST

Colorectal Cancer Screening

This editorial reviews the the US Preventive Services Task Force June 2016 recommendation statement on colorectal cancer screening.
US Preventive Services Task Force Recommendation

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Author Interview

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Interview with Razelle Kurzrock, MD, author of Association of Biomarker-Based Treatment Strategies With Response Rates and Progression-Free Survival in Refractory Malignant Neoplasms: A Meta-analysis

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Association of Biomarker-Based Treatment Strategies With Response Rates and Progression-Free Survival in Refractory Malignant Neoplasms A Meta-analysis

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A Seemingly Solitary Bone Lesion

A white woman in her 60s with a medical history of multiple joint replacements related to osteoarthritis presented with left leg pain; a plain radiograph of the left femur showed a 15-cm area of moderate destruction in the proximal femoral shaft extending distally from the level of the lesser trochanter.

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